Two-Component Signal Transduction Proteins as Potential Drug Targets in Medically Important Fungi

Two-component signal transduction proteins as potential drug targets in medically important fungi.

Two-component signal transduction.

Most prokaryotic signal-transduction systems and a few eukaryotic pathways use phosphotransfer schemes involving two conserved components, a histidine protein kinase and a response regulator protein. The histidine protein kinase, which is regulated by environmental stimuli, autophosphorylates at a histidine residue, creating a high-energy phosphoryl group that is subsequently transferred to an ...

Two-Component Signal Transduction Systems of Pathogenic Bacteria As Targets for Antimicrobial Therapy: An Overview

The bacterial communities in a wide range of environmental niches sense and respond to numerous external stimuli for their survival. Primarily, a source they require to follow up this communication is the two-component signal transduction system (TCS), which typically comprises a sensor Histidine kinase for receiving external input signals and a response regulator that conveys a proper change i...

Two-component signal transduction in Enterococcus faecalis.

Enterococci are gram-positive constituents of the normal human microflora, typically colonizing the intestinal tract and skin (34, 47). However, these organisms are capable of causing disease as opportunistic pathogens, mainly in immunocompromised patients (35, 58). The problem of enterococcal infection has been aggravated by the emergence in the past decade of multiple antibiotic resistance, w...

Two-component signal transduction pathways in Arabidopsis.

The two-component system, consisting of a histidine (His) protein kinase that senses a signal input and a response regulator that mediates the output, is an ancient and evolutionarily conserved signaling mechanism in prokaryotes and eukaryotes. The identification of 54 His protein kinases, His-containing phosphotransfer proteins, response regulators, and related proteins in Arabidopsis suggests...